Expression of a Chemorepellent Factor, Slit2, in Peripheral Nerve Regeneration | Zendy

Toshihiko Tanno | Zendy; Ayumi Fujiwara | Zendy; Shigeo Takenaka | Zendy; Mitsuru Kuwamura | Zendy; Shingo Tsuyama | Zendy

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Expression of a Chemorepellent Factor, Slit2, in Peripheral Nerve Regeneration

Author(s) -

Toshihiko Tanno,

Ayumi Fujiwara,

Shigeo Takenaka,

Mitsuru Kuwamura,

Shingo Tsuyama

Publication year - 2005

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.69.2431

Subject(s) - basal lamina , regeneration (biology) , microbiology and biotechnology , nerve guidance conduit , schwann cell , peripheral nerve , epineurial repair , peripheral , anatomy , chemistry , biology , medicine , ultrastructure

The expression of mRNA for chemorepellent factors slit1 and slit2 in rat peripheral nerve regeneration was examined. The mRNA of slit2 increased when the continuity of basal lamina tubes was disrupted, not when it remained and the Slit2 protein was located in Schwann cells. These results suggest that disruption of the continuity of basal lamina tubes induces the expression of slit2 in Schwann cells during peripheral nerve regeneration.

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