A Role of Androgen Receptor Protein in Cell Growth of an Androgen-Independent Prostate Cancer Cell Line | Zendy

Takashi Furutani | Zendy; Kenichi Takeyama | Zendy; Hiroshi Koutoku | Zendy; Saya Ito | Zendy; Nobuaki Taniguchi | Zendy; Eriko Suzuki | Zendy; Masafumi Kudoh | Zendy; Masayuki Shibasaki | Zendy; Hisataka Shikama | Zendy; Shigeaki Kato | Zendy

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A Role of Androgen Receptor Protein in Cell Growth of an Androgen-Independent Prostate Cancer Cell Line

Author(s) -

Takashi Furutani,

Kenichi Takeyama,

Hiroshi Koutoku,

Saya Ito,

Nobuaki Taniguchi,

Eriko Suzuki,

Masafumi Kudoh,

Masayuki Shibasaki,

Hisataka Shikama,

Shigeaki Kato

Publication year - 2005

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.69.2236

Subject(s) - androgen receptor , prostate cancer , androgen , cancer research , prostate , medicine , androgen deprivation therapy , endocrinology , chemistry , biology , cancer , hormone

Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line using AR ligands and AR siRNA. Although the androgen-independent cell line scarcely responded to AR ligands, their growth was attenuated by ablation of AR protein by siRNA.

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