Y-700, a Novel Inhibitor of Xanthine Oxidase, Suppresses the Development of Colon Aberrant Crypt Foci and Cell Proliferation in 1,2-Dimethylhydrazine-Treated Mice | Zendy

Takao Hashimoto | Zendy; Atsushi Fukunari | Zendy; I. Yamada | Zendy; Noriyuki Yanaka | Zendy; Dong Chen | Zendy; Norihisa Katô | Zendy

Open Access

Y-700, a Novel Inhibitor of Xanthine Oxidase, Suppresses the Development of Colon Aberrant Crypt Foci and Cell Proliferation in 1,2-Dimethylhydrazine-Treated Mice

Author(s) -

Takao Hashimoto,

Atsushi Fukunari,

I. Yamada,

Noriyuki Yanaka,

Dong Chen,

Norihisa Katô

Publication year - 2005

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.69.209

Subject(s) - aberrant crypt foci , xanthine oxidase , 1,2 dimethylhydrazine , crypt , colorectal cancer , dimethylhydrazine , cell growth , chemistry , carcinogenesis , oxidase test , uric acid , biochemistry , cancer research , microbiology and biotechnology , enzyme , cancer , medicine , biology , endocrinology , colonic disease , gene

Y-700, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research