3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole Induces Apoptosis and Necrosis with Activation of Different Caspases in Rat Splenocytes | Zendy

Takashi Hashimoto | Zendy; Takashi Sano | Zendy; Wakana Ito | Zendy; Kazuki Kanazawa | Zendy; Genichi Danno | Zendy; Hitoshi Ashida | Zendy

Open Access

3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole Induces Apoptosis and Necrosis with Activation of Different Caspases in Rat Splenocytes

Author(s) -

Takashi Hashimoto,

Takashi Sano,

Wakana Ito,

Kazuki Kanazawa,

Genichi Danno,

Hitoshi Ashida

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.964

Subject(s) - caspase , apoptosis , proteases , necrosis , tumor necrosis factor alpha , splenocyte , caspase 7 , chemistry , microbiology and biotechnology , caspase 1 , caspase 3 , indole test , programmed cell death , biology , biochemistry , immunology , enzyme , in vitro , genetics

A dietary carcinogen, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) at 20 microM activates caspase-3-like proteases as an apoptotic marker in rat splenocytes. The present study demonstrated 100 microM Trp-P-1 induced necrosis with activation of caspase-3-like proteases. The activation in necrosis and apoptosis resulted from the activation of caspase-9 and caspase-8, respectively. Thus, Trp-P-1 induces apoptosis and necrosis with the activation of different caspases.

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