Suppression of Dioxin Mediated Aryl Hydrocarbon Receptor Transformation by Ethanolic Extracts of Propolis | Zendy

Yong K. Park | Zendy; Itsuko Fukuda | Zendy; Hitoshi Ashida | Zendy; Shin Nishiumi | Zendy; Julio Paredes GUZMAN | Zendy; Hélia Harumi Sato | Zendy; Gláucia María Pastore | Zendy

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Suppression of Dioxin Mediated Aryl Hydrocarbon Receptor Transformation by Ethanolic Extracts of Propolis

Author(s) -

Yong K. Park,

Itsuko Fukuda,

Hitoshi Ashida,

Shin Nishiumi,

Julio Paredes GUZMAN,

Hélia Harumi Sato,

Gláucia María Pastore

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.935

Subject(s) - propolis , aryl hydrocarbon receptor , chemistry , transformation (genetics) , aryl , hydrocarbon , stereochemistry , pharmacology , organic chemistry , food science , biochemistry , biology , alkyl , transcription factor , gene

Present study demonstrated that the ethanolic extracts of propolis containing higher concentrations of flavonoids suppressed 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced aryl hydrocarbon receptor transformation in a dose-dependent manner. The IC(50) values of propolis group 3 and group 12 were 1.2 and 3.6 microg/ml, respectively, indicating that propolis showed stronger antagonistic effects as compared with vegetable extracts.

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