Heterologous Mevalonate Production inStreptomyces lividansTK23 | Zendy

Tomohisa Kuzuyama | Zendy; Tohru Dairi | Zendy; Haruyuki Yamashita | Zendy; Yoshikazu Shoji | Zendy; Haruo Seto | Zendy

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Heterologous Mevalonate Production inStreptomyces lividansTK23

Author(s) -

Tomohisa Kuzuyama,

Tohru Dairi,

Haruyuki Yamashita,

Yoshikazu Shoji,

Haruo Seto

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.931

Subject(s) - heterologous , streptomyces , heterologous expression , farnesyl diphosphate synthase , biology , biochemistry , reductase , mevalonate pathway , terpenoid , biosynthesis , streptomycetaceae , streptomyces albus , gene , enzyme , actinomycetales , genetics , bacteria , recombinant dna

Mevalonate is a ubiquitous biosynthetic intermediate of terpenoids and is used as a moisturizer in cosmetics and a chemical for biochemical research. In this study, we have achieved a heterologous production of this useful compound by expression in Streptomyces lividans TK23 of 3-hydroxy-3-methylglutaryl-CoA synthase and 3-hydroxy-3-methylglutaryl-CoA reductase genes, which were cloned from Streptomyces sp. strain CL190.

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