Fractionation and Anti-tumor Activity of the Mycelia of Liquid-culturedPhellinus linteus | Zendy

Tomoyuki Nakamura | Zendy; Seiichi Matsugo | Zendy; Yasuyuki UZUKA | Zendy; Sumitaka Matsuo | Zendy; Hirokazu Kawagishi | Zendy

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Fractionation and Anti-tumor Activity of the Mycelia of Liquid-culturedPhellinus linteus

Author(s) -

Tomoyuki Nakamura,

Seiichi Matsugo,

Yasuyuki UZUKA,

Sumitaka Matsuo,

Hirokazu Kawagishi

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.868

Subject(s) - phellinus linteus , mycelium , polysaccharide , glucan , chemistry , fractionation , medicinal fungi , biochemistry , chromatography , biology , botany

All the fractions of Phellinus linteus mycelia showed anti-tumor activity toward solid tumors planted in mice. The highest anti-tumor activity of 81.2% was observed in the protein-glucan complex obtained by precipitating the 24% NaOH extract at pH 6.0. This protein-glucan complex consisted of 39.3% polysaccharide and 49.4% protein. Its (13)C- and (1)H-NMR data showed that the main glucan part of the complex was simple alpha-1,3-glucan chains.

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