Open AccessMicroencapsulation of Insulin Microcrystals
Author(s) -
Sung Hee Choi,
Jai-Hyun Kwon,
ChanWha Kim
Publication year - 2004
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.68.749
Subject(s) - plga , insulin , microsphere , chemical engineering , solvent , materials science , chemistry , chromatography , nanotechnology , medicine , organic chemistry , nanoparticle , engineering
Insulin microcrystals were encapsulated (microcrystal/PLGA) within poly(lactide-co-glycolide) (PLGA 50:50) by the multiple emulsification solvent evaporation technique and compared with insulin solution microspheres (solution/PLGA) in terms of their morphology, size distribution, drug content, encapsulation efficiency, and stability of insulin during release.
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