Suppressive Effects of Natural and Synthetic Agents on Dextran Sulfate Sodium-induced Interleukin-1β Release from Murine Peritoneal Macrophages | Zendy

Ki Han Kwon | Zendy; Akira Murakami | Zendy; Hajime Ohigashi | Zendy

Open Access

Suppressive Effects of Natural and Synthetic Agents on Dextran Sulfate Sodium-induced Interleukin-1β Release from Murine Peritoneal Macrophages

Author(s) -

Ki Han Kwon,

Akira Murakami,

Hajime Ohigashi

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.436

Subject(s) - gallic acid , cytokine , rutin , chemistry , inflammation , catechin , interleukin , dextran , pharmacology , immunology , biochemistry , biology , polyphenol , antioxidant

Interleukin (IL)-1beta, an anti-apoptotic and pro-inflammatory cytokine, plays an important role in the onset of inflammation-associated disease. We examined the suppressive effects of a total of 39 synthetic or natural compounds on dextran sulfate sodium-induced IL-1beta production in murine peritoneal macrophages. Several compounds, including alpha-tocopherol, gallic acid, (-)-catechin and rutin, were found to be highly effective for attenuating IL-1beta production, suggesting that they would be useful for anti-inflammatory application.

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