The 9cis,11trans,13cisIsomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells | Zendy

Keisuke Arao | Zendy; Hiroaki Yotsumoto | Zendy; Seo-Young Han | Zendy; Koji Nagao | Zendy; Teruyoshi Yanagita | Zendy

Open Access

The 9cis,11trans,13cisIsomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells

Author(s) -

Keisuke Arao,

Hiroaki Yotsumoto,

Seo-Young Han,

Koji Nagao,

Teruyoshi Yanagita

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.2643

Subject(s) - linolenic acid , conjugated system , chemistry , apolipoprotein b , secretion , fatty acid , biochemistry , alpha linolenic acid , conjugated linoleic acid , stereochemistry , cholesterol , polyunsaturated fatty acid , docosahexaenoic acid , organic chemistry , linoleic acid , polymer

The physiological effects of 9cis,11trans,13cis-conjugated linolenic acid (9c,11t,13c-CLNA), one of the CLNA isomers, were studied in human hepatoma HepG2 cells. 9c,11t,13c-CLNA significantly decreased apolipoprotein B100 secretion compared with alpha-linolenic acid (alpha-LNA). The uptake of (14)C-oleate into newly synthesized cellular triacylglycerol was also decreased by 9c,11t,13c-CLNA more than by alpha-LNA treatment. This is the first study to show the hypolipidemic effect of 9c,11t,13c-CLNA.

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