High Phosphorus Diet Changes Phosphorus Metabolism Regardless of PTH Action in Rats | Zendy

Shin-ichi Katsumata | Zendy; Ritsuko Masuyama | Zendy; Moyuru Koshihara | Zendy; Hiroshi Matsuzaki | Zendy; Mariko Uehara | Zendy; Kazuharu Suzuki | Zendy

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High Phosphorus Diet Changes Phosphorus Metabolism Regardless of PTH Action in Rats

Author(s) -

Shin-ichi Katsumata,

Ritsuko Masuyama,

Moyuru Koshihara,

Hiroshi Matsuzaki,

Mariko Uehara,

Kazuharu Suzuki

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.243

Subject(s) - endocrinology , medicine , parathyroid hormone , bone resorption , excretion , phosphorus , bone remodeling , urinary system , chemistry , metabolism , parathyroidectomy , resorption , calcium , organic chemistry

In this study, we ascertained whether the parathyroid hormone (PTH) dominantly regulated the effects of high phosphorus (P) intakes on urinary excretion of P and bone metabolism in rats. To maintain serum PTH level equally, parathyroidectomy (PTX) and sham-operated rats were constantly exposed to rPTH(1-34) and fed both control (0.3% P) and high P (1.2% P) diet for 7 days, respectively. Urinary excretions of P and C-terminal telopeptides of type I collagen were significantly increased in both PTX and sham rats by the high P diet. These results suggest that high P diet increased urinary P excretion while promoting bone resorption regardless of PTH-dependent regulation.

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