Transcriptional Coactivator p300/CBP-Associated Factor and p300/CBP-Associated Factor Type B Are Required for Normal Estrogen Response of the Mouse Uterus | Zendy

Erina Inoue | Zendy; Miho Hanai | Zendy; Kazuhiko Yamada | Zendy; Takatoshi Esashi | Zendy; Jun Yamauchi | Zendy

Open Access

Transcriptional Coactivator p300/CBP-Associated Factor and p300/CBP-Associated Factor Type B Are Required for Normal Estrogen Response of the Mouse Uterus

Author(s) -

Erina Inoue,

Miho Hanai,

Kazuhiko Yamada,

Takatoshi Esashi,

Jun Yamauchi

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.2209

Subject(s) - pcaf , estrogen , coactivator , estrogen receptor , estrogen receptor alpha , hormone response element , biology , estrogen related receptor alpha , cancer research , endocrinology , transcription factor , medicine , gene , genetics , cancer , breast cancer

Mice with targeted gene disruption of one of the estrogen receptor coactivators, p300/CBP-associated factor (PCAF), and its counterpart, PCAF-B, were used to investigate the possible involvement of PCAF and PCAF-B in estrogen receptor-mediated actions in vivo. Among ovariectomized mice that were treated with estrogen, PCAF and PCAF/PCAF-B knockouts showed abnormal growth of the uterus compared with the wild type. The level of c-fos gene expression in the uterus was not induced by estrogen in the knockouts. These observations suggest that PCAF and PCAF-B are required for estrogen-dependent normal growth of the uterus via estrogen receptor-mediated transcriptional regulations.

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