Structure-activity Relationship for FR901464: A Versatile Method for the Conversion and Preparation of Biologically Active Biotinylated Probes | Zendy

Hajime Motoyoshi | Zendy; Masato Horigome | Zendy; Ken Ishigami | Zendy; Tatsuhiko Yoshida | Zendy; Sueharu Horinouchi | Zendy; Minoru Yoshida | Zendy; Hidenori Watanabe | Zendy; Takeshi Kitahara | Zendy

Open Access

Structure-activity Relationship for FR901464: A Versatile Method for the Conversion and Preparation of Biologically Active Biotinylated Probes

Author(s) -

Hajime Motoyoshi,

Masato Horigome,

Ken Ishigami,

Tatsuhiko Yoshida,

Sueharu Horinouchi,

Minoru Yoshida,

Hidenori Watanabe,

Takeshi Kitahara

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.2178

Subject(s) - biotinylation , biological activity , biotin , conjugate , chemistry , combinatorial chemistry , biochemistry , computational biology , biology , in vitro , mathematical analysis , mathematics

The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.

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