Stimulatory Effects of Casein Phosphopeptide (CPP-III) on mRNA Expression of Cytokines in Caco-2 Cells | Zendy

Takeshi Kawahara | Zendy; Hajime Otani | Zendy

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Stimulatory Effects of Casein Phosphopeptide (CPP-III) on mRNA Expression of Cytokines in Caco-2 Cells

Author(s) -

Takeshi Kawahara,

Hajime Otani

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.1779

Subject(s) - phosphopeptide , casein , messenger rna , caco 2 , lactobacillus acidophilus , lipopolysaccharide , microbiology and biotechnology , chemistry , tumor necrosis factor alpha , lactobacillus , biology , probiotic , biochemistry , bacteria , cell , phosphorylation , gene , immunology , genetics , fermentation

The effect of CPP-III, a commercially available casein phosphopeptide, on the mRNA expression of cytokines in Caco-2 cells was investigated. CPP-III enhanced the mRNAs of interleukin (IL)-6 and tumor necrosis factor-alpha while IL-1beta was not affected. The mRNA expression of IL-6 was stronger in the presence of both CPP-III and bacterial components such as peptidoglycan from Lactobacillus acidophilus and lipopolysaccharide from Salmonella typhimurium. These results suggest that CPP-III influences the expression of cytokines in intestinal epithelial cells.

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