Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract | Zendy

Taichi Yamamoto | Zendy; Mineka Yoshimura | Zendy; Fumio Yamaguchi | Zendy; Tomoko Kouchi | Zendy; Ryohei Tsuji | Zendy; Makoto Saito | Zendy; Akio Obata | Zendy; Mamoru Kikuchi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract

Author(s) -

Taichi Yamamoto,

Mineka Yoshimura,

Fumio Yamaguchi,

Tomoko Kouchi,

Ryohei Tsuji,

Makoto Saito,

Akio Obata,

Mamoru Kikuchi

Publication year - 2004

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.68.1706

Subject(s) - naringenin , histamine , rutin , chalcone , chemistry , in vivo , in vitro , polyphenol , chlorogenic acid , pharmacology , flavonoid , biochemistry , food science , biology , antioxidant , stereochemistry , microbiology and biotechnology

The anti-allergic activity of a tomato extract was studied by using an in vitro histamine-release assay. The tomato skin extract exerted the strongest inhibition of histamine release. Chlorogenic acid, rutin and naringenin were identified in the 60% ethanol extract of tomato skin. However, the extract contained an unknown compound which strongly inhibited histamine release. This active compound in tomato skin was identified as naringenin chalcone (trans-2'4'6'4-tetrahydroxychalcone). Naringenin chalcone inhibited histamine release with an IC(50) value of 68 microg/ml. The anti-allergic activity of the tomato skin extract was next investigated by the in vivo mouse ear-swelling response. We found that naringenin chalcone showed the strongest inhibitory effect of the polyphenols of the tomato skin extract. These results indicate that a tomato skin extract could inhibit allergic reactions.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research