Stereochemistry of 2-Phenylethylamine Oxidation Catalyzed by Bacterial Copper Amine Oxidase | Zendy

Mayumi Uchida | Zendy; Akifumi OHTANI | Zendy; Naoki Kohyama | Zendy; Toshihide Okajima | Zendy; Katsuyuki Tanizawa | Zendy; Yukio Yamamoto | Zendy

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Stereochemistry of 2-Phenylethylamine Oxidation Catalyzed by Bacterial Copper Amine Oxidase

Author(s) -

Mayumi Uchida,

Akifumi OHTANI,

Naoki Kohyama,

Toshihide Okajima,

Katsuyuki Tanizawa,

Yukio Yamamoto

Publication year - 2003

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.67.2664

Subject(s) - chemistry , phenylacetaldehyde , stereospecificity , amine gas treating , amine oxidase , copper , deuterium , catalysis , substrate (aquarium) , hydrogen atom abstraction , amine oxidase (copper containing) , gas chromatography , enzyme , mass spectrometry , enzyme catalysis , stereochemistry , organic chemistry , hydrogen , chromatography , diamine oxidase , physics , oceanography , quantum mechanics , geology

The stereochemical course of the reaction catalyzed by a copper amine oxidase from Arthrobacter globiformis has been investigated using 2-phenylethylamine stereospecifically deuterium-labeled at the C1 position. Measurements of deuterium content in the product, phenylacetaldehyde, by gas chromatography-mass spectrometry revealed stereospecific abstraction of the pro-S hydrogen during the enzymatic oxidation, as predicted from the structure modeling for the enzyme-bound substrate.

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