Effect of α,α-Dialkyl Amino Acids on the Protease Resistance of Peptides | Zendy

Hiroshi Yamaguchi | Zendy; Hiroaki Kodama | Zendy; Satoshi Osada | Zendy; Fumio Kato | Zendy; Masood JelokhaniNiaraki | Zendy; Michio Kondo | Zendy

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Effect of α,α-Dialkyl Amino Acids on the Protease Resistance of Peptides

Author(s) -

Hiroshi Yamaguchi,

Hiroaki Kodama,

Satoshi Osada,

Fumio Kato,

Masood JelokhaniNiaraki,

Michio Kondo

Publication year - 2003

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.67.2269

Subject(s) - peptide , protease , amino acid , chemistry , aminoisobutyric acid , amino acid residue , biochemistry , oligopeptide , peptide sequence , enzyme , gene

A tryptic [EC 3.4.21.4] digestion assay of 2-aminoisobutyric acid (Aib)-containing peptides was carried out to investigate the effect of alpha,alpha-dialkyl amino acid residues on the protease resistance. The introduction of Aib residues to the P1' positions exhibited a 19-fold higher protease resistance than the peptide with Aib residues introduced to the P2 position or the non-Aib peptide. The peptide having Aib residues introduced to the P1' and P2 positions resulted in complete resistance.

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