Myrsinoic Acid E, an Anti-inflammatory Compound fromMyrsine seguinii | Zendy

Hidefumi Makabe | Zendy; Shintaro Miyazaki | Zendy; Tsunashi Kamo | Zendy; Mitsuru Hirota | Zendy

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Myrsinoic Acid E, an Anti-inflammatory Compound fromMyrsine seguinii

Author(s) -

Hidefumi Makabe,

Shintaro Miyazaki,

Tsunashi Kamo,

Mitsuru Hirota

Publication year - 2003

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.67.2038

Subject(s) - benzoic acid , chemistry , anti inflammatory , stereochemistry , inflammation , pharmacology , biochemistry , medicine , immunology

The methanolic extract of Myrsine seguinii yielded the novel anti-inflammatory compound, myrsinoic acid E (1), whose structure was elucidated to be 3,5-digeranyl-4-hydroxy benzoic acid. We synthesized 1- and its 3,5-diprenyl (2) and 3,5-difarnesyl analogues (3). Compounds 1-3 suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears by 59%, 14%, and 69% at a dose of 1.4 micromol.

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