Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants ofEscherichia coli | Zendy

Yoshiko Sakamoto | Zendy; Soichi Furukawa | Zendy; Hirokazu Ogihara | Zendy; Makari Yamasaki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants ofEscherichia coli

Author(s) -

Yoshiko Sakamoto,

Soichi Furukawa,

Hirokazu Ogihara,

Makari Yamasaki

Publication year - 2003

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.67.2030

Subject(s) - fosfomycin , adenylate kinase , cyclase , escherichia coli , mutant , biology , biochemistry , microbiology and biotechnology , gene , genetics , enzyme , antibiotics

Adenylate cyclase deficient (cya) mutants of E. coli K-12 were found to be resistant to fosmidomycin, a specific inhibitor of the non-mevalonate pathway, just like to fosfomycin. E. coli glpT mutants were resistant to fosfomycin and also to fosmidomycin. This fact shows that fosmidomycin was transported inside via the glycerol-3-phosphate transporter, GlpT. DNA micro-array analysis showed that the transcription of glpT and other genes concerning glycerol utilization were highly dependent on the presence of cAMP.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research