Anti-angiogenic Activity of Tocotrienol | Zendy

H. Inokuchi | Zendy; H. Hirokane | Zendy; T. Tsuzuki | Zendy; Kiyotaka Nakagawa | Zendy; Miki Igarashi | Zendy; Teruo Miyazawa | Zendy

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Anti-angiogenic Activity of Tocotrienol

Author(s) -

H. Inokuchi,

H. Hirokane,

T. Tsuzuki,

Kiyotaka Nakagawa,

Miki Igarashi,

Teruo Miyazawa

Publication year - 2003

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.67.1623

Subject(s) - tocotrienol , umbilical vein , angiogenesis , vitamin e , in vitro , tocopherol , pharmacology , chemistry , medicine , biochemistry , cancer research , antioxidant

The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with delta-tocotrienol appearing the highest activity. Also, delta-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.

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