Conjugated Linoleic Acid (CLA) Inhibits Fatty Acid Synthetase Activityin Vitro | Zendy

Hirosuke Oku | Zendy; Sawitree Wongtangtintharn | Zendy; Hironori Iwasaki | Zendy; Takayoshi Toda | Zendy

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Conjugated Linoleic Acid (CLA) Inhibits Fatty Acid Synthetase Activityin Vitro

Author(s) -

Hirosuke Oku,

Sawitree Wongtangtintharn,

Hironori Iwasaki,

Takayoshi Toda

Publication year - 2003

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.67.1584

Subject(s) - conjugated linoleic acid , biosynthesis , fatty acid , biochemistry , linoleic acid , in vitro , enzyme , chemistry , fatty acid synthase , fatty acid synthesis

This paper describes the in vitro effect of conjugated linoleic acid (CLA) on fatty acid biosynthesis. Among the rat liver enzymes involved in fatty acid biosynthesis, fatty acid synthetase (FAS) showed the largest activity fluctuation with the types of fatty acids. Of the fatty acids, CLA was the most potent inhibitor of FAS, and the 9c, 11t-rather than the 10t, 12c-isomer showed greater inhibition. CLA also significantly lowered the incorporation of [14C]-acetate into phospholipid in breast cancer cells, supporting the view that CLA inhibits fatty acid biosynthesis through the interaction with FAS.

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