Hypoglycemic Effect of aLentinus edodesExo-polymer Producedfrom a Submerged Mycelial Culture | Zendy

Byung-Keun Yang | Zendy; Dong-Hyun Kim | Zendy; SangChul Jeong | Zendy; Surajit Das | Zendy; Youngsun Choi | Zendy; JoonShik Shin | Zendy; Sangchul Lee | Zendy; ChiHyun Song | Zendy

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Hypoglycemic Effect of aLentinus edodesExo-polymer Producedfrom a Submerged Mycelial Culture

Author(s) -

Byung-Keun Yang,

Dong-Hyun Kim,

SangChul Jeong,

Surajit Das,

Youngsun Choi,

JoonShik Shin,

Sangchul Lee,

ChiHyun Song

Publication year - 2002

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.66.937

Subject(s) - lentinus , mycelium , chemistry , triglyceride , sugar , carbohydrate , streptozotocin , plasma glucose , polymer , glycoprotein , food science , cholesterol , biochemistry , insulin , chromatography , diabetes mellitus , biology , organic chemistry , botany , endocrinology , mushroom

The hypoglycemic effect of an exo-polymer produced from a submerged mycelial culture of Lentinus edodes was investigated in streptozotocin-induced diabetic rats. The administration of the exo-polymer (200 mg/kg BW) reduced the plasma glucose level by as much as 21.5%, and increased plasma insulin by 22.1% as compared to the control group. It also lowered the plasma total cholesterol and triglyceride levels by 25.1 and 44.5%, respectively. Gel chromatography of the exo-polymer revealed a single peak which is likely to have been a glycoprotein with a molecular weight of 52 kDa and was found to contain 83.5% carbohydrate and 16.5% protein. The Sugar and amino acid compositions of the exo-polymer were analyzed in detail.

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