Prevention by Polyhydroxysteroids and Saponins ofAsterina pectiniferaof the Desquamation of Stratum Corneum Cells | Zendy

Kazuyo Ukai | Zendy; Atsufumi Iwanaga | Zendy; Hiroshi Nagai | Zendy; Michio Namikoshi | Zendy

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Prevention by Polyhydroxysteroids and Saponins ofAsterina pectiniferaof the Desquamation of Stratum Corneum Cells

Author(s) -

Kazuyo Ukai,

Atsufumi Iwanaga,

Hiroshi Nagai,

Michio Namikoshi

Publication year - 2002

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.66.913

Subject(s) - stratum corneum , desquamation , chemistry , guinea pig , pharmacology , traditional medicine , biochemistry , biology , dermatology , medicine , endocrinology , genetics

Two polyhydroxysteroids and three steroidal saponins (pectiniosides A, B and C) were isolated as bioactive substances from Asterina pectinifera. These compounds inhibited the release of guinea-pig skin stratum corneum cells by 48-67% (control, 0%) at 2 mg/ml. It is suggested that the bioactivity of these compounds is connected with the remedial and preventive effects of an aqueous extract of A. pectinifera on rough human skin.

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