Open AccessTotal Synthesis of (±)-syn-Copalol
Author(s) -
Hiroaki Toshima,
Hideaki Oikawa,
Hiroshi Yada,
Hiroshi Ono,
Tomonobu Toyomasu,
Takeshi Sassa
Publication year - 2002
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.66.2504
Subject(s) - total synthesis , chemistry , stereochemistry
The labdane diterpene derivative, syn-copalol [(+)-5] is the alcohol part of syn-copalyl diphosphate [(+)-4]. In this paper, racemic (+/-)-5 was synthesized from a known racemic lactone in 8 steps. The current and our previous syntheses provide all four copalol derivatives [(+)-3, (-)-3 and (+/-)-5] which are required for the biosynthetic study of polycyclic diterpenes.
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