A Major Decomposition Product, Citrinin H2, from Citrinin on Heating with Moisture | Zendy

Mitsuru Hirota | Zendy; Alka MENTA | Zendy; Keiko Yoneyama | Zendy; Naofumi Kitabatake | Zendy

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A Major Decomposition Product, Citrinin H2, from Citrinin on Heating with Moisture

Author(s) -

Mitsuru Hirota,

Alka MENTA,

Keiko Yoneyama,

Naofumi Kitabatake

Publication year - 2002

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.66.206

Subject(s) - citrinin , penicillium citrinum , cytotoxicity , chemistry , mycotoxin , incubation , food science , chromatography , biochemistry , in vitro

Citrinin is one of the mycotoxins produced by Penicillium citrinum. We examined the decomposition products after heating citrinin in water at 140 degrees C and isolated a major product, citrinin H2 (3-(3,5-dihydroxy-2-methylphenyl)-2-formyloxy-butane). Citrinin H2 did not show significant cytotoxicity to HeLa cells up to a concentration of 200 microg/ml (% cytotoxicity: 39%) in 63 h of incubation, but citrinin showed severe toxicity at a concentration of 25 microg/ml (% cytotoxicity: 73%). HPLC analysis of citrinin after heating under various conditions indicates that citrinin H2 is mainly yielded from citrinin.

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