α-Glucosidase Inhibitory Activity of a 70% Methanol Extract from Ezoishige (Pelvetia babingtoniide Toni) and Its Effect on the Elevation of Blood Glucose Level in Rats | Zendy

Tomoki Ohta | Zendy; Shigefumi Sasaki | Zendy; Tadashi OOHORI | Zendy; Shuji Yoshikawa | Zendy; Hideyuki Kurihara | Zendy

Open Access

α-Glucosidase Inhibitory Activity of a 70% Methanol Extract from Ezoishige (Pelvetia babingtoniide Toni) and Its Effect on the Elevation of Blood Glucose Level in Rats

Author(s) -

Tomoki Ohta,

Shigefumi Sasaki,

Tadashi OOHORI,

Shuji Yoshikawa,

Hideyuki Kurihara

Publication year - 2002

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.66.1552

Subject(s) - postprandial , sucrase , maltase , sucrose , alpha glucosidase , chemistry , medicine , endocrinology , enzyme , biochemistry , diabetes mellitus

The 70% methanol extract from ezoishige (Pelvetia babingtonii de Toni) inhibited the rat-intestinal alpha-glucosidase, sucrase and maltase activities, with IC50 values of 2.24 and 2.84 mg/ml. Sucrose was orally administered with or without the extract to rats at 1000 mg/kg. The postprandial elevation in the blood glucose level at 15 and 30 min after the administration of sucrose with the extract was significantly suppressed when compared with the control. These results suggest that the extract from ezoishige has potent alpha-glucosidase inhibitors and would be effective for suppressing postprandial hyperglycemia.

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