Soybean Resistant Proteins Interrupt an Enterohepatic Circulation of Bile Acids and Suppress Liver Tumorigenesis Induced by Azoxymethane and Dietary Deoxycholate in Rats | Zendy

Ryuhei Kanamoto | Zendy; Naoyuki AZUMA | Zendy; T. Miyamoto | Zendy; Tohru SAEKI | Zendy; Yasunari Tsuchihashi | Zendy; Kimikazu Iwami | Zendy

Open Access

Soybean Resistant Proteins Interrupt an Enterohepatic Circulation of Bile Acids and Suppress Liver Tumorigenesis Induced by Azoxymethane and Dietary Deoxycholate in Rats

Author(s) -

Ryuhei Kanamoto,

Naoyuki AZUMA,

T. Miyamoto,

Tohru SAEKI,

Yasunari Tsuchihashi,

Kimikazu Iwami

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.999

Subject(s) - azoxymethane , enterohepatic circulation , medicine , chemistry , carcinogenesis , reabsorption , endocrinology , biochemistry , bile acid , biology , cancer , kidney

We found that azoxymethane and dietary deoxycholate induced liver tumors in rats. The incidence and the development of the tumor were closely related to the enterohepatic circulation of bile acids. The feeding of a high-molecular-weight fraction of soy protein digest (HMF) suppressed the tumorigenesis, probably due to the inhibitory effect of soybean resistant protein on reabsorption of bile acids in the intestine.

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