Synthesis of Gibbilimbols A-D, Cytotoxic and Antibacterial Alkenylphenols Isolated from Piper gibbilimbum | Zendy

Yumi Abe | Zendy; Hirosato Takikawa | Zendy; Kenji MORI | Zendy

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Synthesis of Gibbilimbols A-D, Cytotoxic and Antibacterial Alkenylphenols Isolated from Piper gibbilimbum

Author(s) -

Yumi Abe,

Hirosato Takikawa,

Kenji MORI

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.732

Subject(s) - phenol , piper , cytotoxic t cell , chemistry , antibacterial activity , traditional medicine , phenols , stereochemistry , organic chemistry , bacteria , biology , in vitro , biochemistry , medicine , genetics

Gibbilimbols A [(E)-4-(4-decenyl)phenol, 1], B [(E)-4-(3-decenyl)phenol, 2], C [(E)-4-(4-octenyl)phenol, 3] and D [(E)-4-(3-octenyl)phenol, 4] were synthesized by coupling the phenolic parts with the alkyne parts and then reducing the triple bond of the resulting alkynylphenols. These alkenylphenols (1-4) are the cytotoxic and antibacterial constituents of the leaves of a medicinal plant (Piper gibbilimbum) that is used as a traditional medicine in Papua New Guinea.

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