Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B | Zendy

K Togashi | Zendy; Hack-Ryong Ko | Zendy; Jong-Seog Ahn | Zendy; Hiroyuki Osada | Zendy

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Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B

Author(s) -

K Togashi,

Hack-Ryong Ko,

Jong-Seog Ahn,

Hiroyuki Osada

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.651

Subject(s) - telomerase , telomerase reverse transcriptase , reverse transcriptase , fungus , enzyme , nucleotidyltransferase , chemistry , microbiology and biotechnology , biology , biochemistry , rna , gene , botany

We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 microM, respectively. These compounds also inhibited the activity of viral reverse transcriptase at almost the same dose levels which inhibited telomerase activity.

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