Effects of 2,3-Diketo-L-gulonic Acid on the Oxidation of Yolk Lipoprotein | Zendy

Meihua Li | Zendy; Emiko Suzuki | Zendy; Tadao KURATA | Zendy

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Effects of 2,3-Diketo-L-gulonic Acid on the Oxidation of Yolk Lipoprotein

Author(s) -

Meihua Li,

Emiko Suzuki,

Tadao KURATA

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.599

Subject(s) - chemistry , ascorbic acid , oxidative phosphorylation , aqueous solution , medicinal chemistry , biochemistry , organic chemistry , food science

2,3-Diketo-L-gulonic acid (DKG) is an important intermediate product of oxidative degradation of L-ascorbic acid (AsA) in both biological and food systems, but the physiological function of DKG is still unclear. In this study, it was found that DKG had a strong antioxidative effect on copper-dependent oxidative modification of yolk lipoprotein (YLP), on the basis of both the decreased electrophoretic mobility and longer lag time of conjugated diene formation in a concentration-dependent manner. DKG is known to be very unstable and easily converts into two delta-lactones of DKG, the 3,4-enediol form of DKG delta-lactone (3,4-DKGL) and 2,3-enediol form of DKG delta-lactone (2,3-DKGL) depending on both pH and temperature. 3,4-DKGL was thought to be the first degradation product of DKG and could play an antioxidative role in the oxidation of lipoproteins induced by copper ion or peroxyl radicals in neutral aqueous solution.

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