Inhibitory Effects of Ellagi- and Gallotannins on Rat Intestinal α-Glucosidase Complexes | Zendy

Miou Toda | Zendy; Jun Kawabata | Zendy; Takanori Kasai | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inhibitory Effects of Ellagi- and Gallotannins on Rat Intestinal α-Glucosidase Complexes

Author(s) -

Miou Toda,

Jun Kawabata,

Takanori Kasai

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.542

Subject(s) - sucrase , maltase , alpha glucosidase , chemistry , biochemistry , glucosidases , enzyme , acarbose , inhibitory postsynaptic potential , stereochemistry , biology , endocrinology

The clove ellagitannins and their related polygalloyl-glucoses inhibited maltase activity of rat intestinal alpha-glucosidases. The structure-activity relationship study of those galloylglucoses, varying the extent of galloylation on the glucose core, with the ellagitannins, indicated that an increasing number of galloyl units in the molecule lead to an increase in the inhibitory activity. Penta-O-galloyl-beta-D-glucose, with five galloyl groups showed the highest inhibitory activity. On the other hand, hexahydroxydiphenoyl units contained in the ellagitannins had little effect on the activity. After separation of maltase-glucoamylase and sucrase-isomaltase complexes from the crude mixture of the rat alpha-glucosidases, the inhibitory activities of the galloylglucose derivatives against each complex were examined. The inhibitory influence on the maltase-glucoamylase complex was more potent than on the sucrase-isomaltase complex.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research