Isolation and Primary Structural Analysis of Two Conjugated Polyketone Reductases from Candida parapsilosis | Zendy

Aklani-Rose G.D. HIDALGO | Zendy; Muhammad Ali Akond | Zendy; Keiko Kita | Zendy; Michihiko Kataoka | Zendy; Sakayu Shimizu | Zendy

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Isolation and Primary Structural Analysis of Two Conjugated Polyketone Reductases from Candida parapsilosis

Author(s) -

Aklani-Rose G.D. HIDALGO,

Muhammad Ali Akond,

Keiko Kita,

Michihiko Kataoka,

Sakayu Shimizu

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.2785

Subject(s) - candida parapsilosis , conjugated system , amino acid residue , biochemistry , enzyme , amino acid , structural similarity , chemistry , active site , protein primary structure , isolation (microbiology) , antifungal , biology , peptide sequence , gene , microbiology and biotechnology , organic chemistry , polymer

Two conjugated polyketone reductases (CPRs) were isolated from Candida parapsilosis IFO 0708. The primary structures of CPRs (C1 and C2) were analyzed by amino acid sequencing. The amino acid sequences of both enzymes had high similarity to those of several proteins of the aldo-keto-reductase (AKR) superfamily. However, several amino acid residues in the putative active sites of AKRs were not conserved in CPRs-C1 and -C2.

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