Synthesis of Southern (C1'-C11') and Eastern (C8-C18) Fragments of Pamamycin-607, an Aerial Mycelium-inducing Substance of Streptomyces alboniger | Zendy

Hiromasa Kiyota | Zendy; Yukito FURUYA | Zendy; Shigefumi Kuwahara | Zendy; Takayuki Oritani | Zendy

Open Access

Synthesis of Southern (C1'-C11') and Eastern (C8-C18) Fragments of Pamamycin-607, an Aerial Mycelium-inducing Substance of Streptomyces alboniger

Author(s) -

Hiromasa Kiyota,

Yukito FURUYA,

Shigefumi Kuwahara,

Takayuki Oritani

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.2630

Subject(s) - mycelium , aldol reaction , yield (engineering) , streptomyces , epoxide , stereochemistry , fragment (logic) , chemistry , botany , biology , bacteria , organic chemistry , catalysis , materials science , mathematics , genetics , algorithm , metallurgy

Synthesis of the southern C1'-C11' and eastern C8-C18 fragments of pamamycin-607, an aerial mycelium-inducing substance of Streptomyces alboniger, was achieved. The southern fragment was synthesized by using the Evans aldol reaction and cis-selective iodoetherification as the key steps in a 9.6% overall yield (7 steps). The eastern fragment was constructed via the Julia coupling reaction and cis-selective iodoetherification in a 3.0% overall yield (8 steps from the known epoxide).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research