Purification and Characterization of Two Lectins from a Toxic Moray, Gymnothrax javanicus | Zendy

Hirokazu Kawagishi | Zendy; M Yasui | Zendy; Akinori Uno | Zendy; Takeomi Murata | Zendy; Taichi Usui | Zendy; Syoei FURUKAWA | Zendy

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Purification and Characterization of Two Lectins from a Toxic Moray, Gymnothrax javanicus

Author(s) -

Hirokazu Kawagishi,

M Yasui,

Akinori Uno,

Takeomi Murata,

Taichi Usui,

Syoei FURUKAWA

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.2437

Subject(s) - lectin , biochemistry , mucin , glycoconjugate , hemagglutination , glycoprotein , chemistry , molecular mass , biology , microbiology and biotechnology , antigen , immunology , enzyme

Two lectins, Gymnothrax javanicus lectin-I (GJL-I) and Gymnothrax javanicus lectin-II (GJL-II) were isolated from the stomach and intestine, and the liver, respectively, of a toxic moray eel, Gymnothrax javanicus. GJL-I is a polymer of two heterogeneous subunits of 67 and 51 kDa. In a hemagglutination inhibition assay, it had sugar-binding specificity toward lactose and lactulose among the mono- or oligo-saccharides and bovine submaxillary mucin (BSM) among the glycoproteins tested. The lectin stimulated nerve growth factor (NGF) synthesis by astroglial cells. GJL-II was a polymer of subunit of 41 kDa. This lectin had N-acetyllactosamine binding specificity.

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