Dehydroascorbic Acid Reduction in Several Tissues and Cultured Hepatocytes of the Chicken | Zendy

Keisuke Sasaki | Zendy; Yasunari Kitaguchi | Zendy; Kengo Koga | Zendy; Rei Narita | Zendy; Tatsuki Fukuda | Zendy; Yosuke Aoyagi | Zendy

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Dehydroascorbic Acid Reduction in Several Tissues and Cultured Hepatocytes of the Chicken

Author(s) -

Keisuke Sasaki,

Yasunari Kitaguchi,

Kengo Koga,

Rei Narita,

Tatsuki Fukuda,

Yosuke Aoyagi

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.2288

Subject(s) - dehydroascorbic acid , ascorbic acid , cytosol , biochemistry , chemistry , glutathione , chicken liver , enzyme , food science

Dehydroascorbic acid, the oxidized form of ascorbic acid, is rapidly reduced to ascorbate in living organs (ascorbate recycling). We examined the GSH-dependent dehydroascorbate reductase activity in several tissues of the chicken. The activity was highest in the liver, and second highest in the brain. The activity was localized in the cytosol fraction of the liver. We subsequently examined the dehydroascorbate reduction in separated chicken hepatocytes. The cellular ascorbate concentration was elevated in dehydroascorbate-treated cells. It is thought that hepatocytes incorporated external dehydroascorbate and converted it into ascorbate. These findings suggest that the liver plays an important role in ascorbate recycling by the chicken.

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