Open AccessEnzymatic Glycosylation of Lincomycin
Author(s) -
Lenka Weignerová,
J. Spížek,
Lucie Najmanová,
Vladimı́r Křen
Publication year - 2001
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.65.1897
Subject(s) - lincomycin , glycosidic bond , glycosylation , chemistry , enzyme , bacteria , biochemistry , antibiotics , microbiology and biotechnology , stereochemistry , biology , genetics
Lincomycin (1), a glycosidic antibiotic, active against Gram-positive bacteria, was modified enzymatically with the aim of improving its physico-chemical and biological properties. Compound 1 was glycosylated using jack bean alpha-mannosidase to produce 7-O-alpha-D-mannopyranosyl-lincomycin (2).
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