Acetyl-CoA Carboxylase Inhibitors from Avocado (Persea americana Mill) Fruits | Zendy

Hironori HASHIMURA | Zendy; Chihoko Ueda | Zendy; Jun Kawabata | Zendy; Takanori Kasai | Zendy

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Acetyl-CoA Carboxylase Inhibitors from Avocado (Persea americana Mill) Fruits

Author(s) -

Hironori HASHIMURA,

Chihoko Ueda,

Jun Kawabata,

Takanori Kasai

Publication year - 2001

Publication title -

bioscience biotechnology and biochemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.65.1656

Subject(s) - persea , pyruvate carboxylase , enzyme , ic50 , acetyl coa carboxylase , chemistry , methanol , lauraceae , stereochemistry , biochemistry , botany , biology , in vitro , organic chemistry

A methanol extract of avocado fruits showed potent inhibitory activity against acetyl-CoA carboxylase, a key enzyme in fatty acid biosynthesis. The active principles were isolated and identified as (5E,12Z,15Z)-2-hydroxy-4-oxoheneicosa-5,12,15-trienyl (1), (2R,12Z,15Z)-2-hydroxy-4-oxoheneicosa-12,15-dienyl (2), (2R*,4R*)-2,4-dihydroxyheptadec-16-enyl (3) and (2R*,4R*)-2,4-dihydroxyheptadec-16-ynyl (4) acetates by instrumental analyses. The IC50 of the compounds were 4.0 x 10(-6), 4.9 x 10(-6), 9.4 x 10(-6), and 5.1 x 10(-6) M, respectively.

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