Resolution and Synthesis of Optically Active Alcohols with Immobilized Water-soluble Proteins from Green Pea, Soybean and Buckwheat as New Bio-catalysts | Zendy

Hiroyuki Nagaoka | Zendy; Hiroshi Kayahara | Zendy

Open Access

Resolution and Synthesis of Optically Active Alcohols with Immobilized Water-soluble Proteins from Green Pea, Soybean and Buckwheat as New Bio-catalysts

Author(s) -

Hiroyuki Nagaoka,

Hiroshi Kayahara

Publication year - 2000

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.64.781

Subject(s) - oxidizing agent , alcohol , enantiomer , chemistry , optically active , ethanol , kinetic resolution , yield (engineering) , resolution (logic) , catalysis , enantiomeric excess , organic chemistry , chromatography , enantioselective synthesis , materials science , artificial intelligence , computer science , metallurgy

Kinetic resolution of racemic alcohols, (+/-)-1-(4-substituted phenyl)ethanol and (+/-)-1-(2-naphthyl)ethanol, was done with immobilized green pea, soybean, or buckwheat proteins. The resolution was done stereoselectively by oxidizing only one enantiomer of a racemic alcohol to leave an optically active alcohol with a high purity. In addition, each protein could be reused consecutively at least three times without any decrease of yield or optical purity.

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