Open AccessBiosynthesis of Depudecin, a Metabolite ofNimbya scirpicola
Author(s) -
Masayasu Tanaka,
Takane Fujimori,
Kensuke Nabeta
Publication year - 2000
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.64.244
Subject(s) - polyketide , biosynthesis , metabolite , epoxide , chemistry , stereochemistry , deuterium , biochemistry , enzyme , catalysis , physics , quantum mechanics
Feeding experiments of labeled acetates to Nimbya scirpicola proved the carbon origin of the straight-chain polyketide, depudecin. Differential hydrogen exchange of the 2H label originating from 2H labeled acetate along the polyketide chain occurred. In particular, the deuterium of an epoxide methine at C-3 was lost to a substantial extent in the formation of depudecin.
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