Suppression ofD-Galactosamine-induced Liver Injury by Mushrooms in Rats | Zendy

EunWoo Lee | Zendy; Puming He | Zendy; Hirokazu Kawagishi | Zendy; Kimio SUGIYAMA | Zendy

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Suppression ofD-Galactosamine-induced Liver Injury by Mushrooms in Rats

Author(s) -

EunWoo Lee,

Puming He,

Hirokazu Kawagishi,

Kimio SUGIYAMA

Publication year - 2000

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.64.2001

Subject(s) - grifola frondosa , mushroom , galactosamine , liver injury , chemistry , edible mushroom , biochemistry , mushroom poisoning , liver damage , pharmacology , food science , medicine , endocrinology , biology , glucosamine

Six species of edible mushroom were found to suppress D-galactosamine-induced enhancement of plasma alanine and aspartate aminotransferase activities when powdered mushrooms were added to the diet (5%) and fed to rats for 2 wk. Grifola frondosa exhibited the most potent effect in a dose-dependent manner. A significant effect was observed only from the water-soluble low-molecular-weight fraction of G. frondosa. The results indicate that several mushrooms possess a protective effect against liver injury induced by D-galactosamine.

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