Asymmetric Reduction of Ethyl 2-methyl 3-oxobutanoate by Fungi | Zendy

Kenzo IWAMOTO | Zendy; Takayuki Kuramoto | Zendy; Minoru Izumi | Zendy; Mitsunori Kirihata | Zendy; Takaaki Dohmaru | Zendy; Fumiki Yoshizako | Zendy

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Asymmetric Reduction of Ethyl 2-methyl 3-oxobutanoate by Fungi

Author(s) -

Kenzo IWAMOTO,

Takayuki Kuramoto,

Minoru Izumi,

Mitsunori Kirihata,

Takaaki Dohmaru,

Fumiki Yoshizako

Publication year - 2000

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.64.194

Subject(s) - diastereomer , enantiomer , enantiomeric excess , penicillium , chemistry , medicinal chemistry , stereochemistry , organic chemistry , food science , enantioselective synthesis , catalysis

Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S,3S)- and syn-(2S,3R)- hydroxy esters of 90 and >99 ee%, respectively.

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