1,1-Diphenyl-2-picrylhydrazyl Radical-scavenging Compounds from Soybean Miso and Antiproliferative Activity of Isoflavones from Soybean Miso toward the Cancer Cell Lines | Zendy

Akira Hirota | Zendy; Shoji TAKI | Zendy; Satoru Kawaii | Zendy; Masamichi Yano | Zendy; Naoki Abe | Zendy

Open Access

1,1-Diphenyl-2-picrylhydrazyl Radical-scavenging Compounds from Soybean Miso and Antiproliferative Activity of Isoflavones from Soybean Miso toward the Cancer Cell Lines

Author(s) -

Akira Hirota,

Shoji TAKI,

Satoru Kawaii,

Masamichi Yano,

Naoki Abe

Publication year - 2000

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.64.1038

Subject(s) - isoflavones , scavenging , chemistry , cancer , biochemistry , medicine , antioxidant

Guided by their DPPH radical-scavenging activity, nine compounds were isolated from soybean miso. Of these, 8-hydroxydaidzein, 8-hydroxygenistein and syringic acid had as high DPPH radical-scavenging activity as that of alpha-tocopherol. The antiproliferative activity of four of the isolated isoflavones toward three cancer cell lines was examined. 8-Hydroxygenistein showed the highest activity (IC50=5.2 microM) toward human promyelocytic leukemia cells (HL-60).

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