Inhibition of Iron/Ascorbate-Induced Lipid Peroxidation by an N-Terminal Peptide of Bovine Lactoferrin and Its Acylated Derivatives | Zendy

Hiroyuki Wakabayashi | Zendy; Hiroshi Matsumoto | Zendy; Koichi Hashimoto | Zendy; Susumu Teraguchi | Zendy; Mitsunori Takase | Zendy; Hirotoshi Hayasawa | Zendy

Open Access

Inhibition of Iron/Ascorbate-Induced Lipid Peroxidation by an N-Terminal Peptide of Bovine Lactoferrin and Its Acylated Derivatives

Author(s) -

Hiroyuki Wakabayashi,

Hiroshi Matsumoto,

Koichi Hashimoto,

Susumu Teraguchi,

Mitsunori Takase,

Hirotoshi Hayasawa

Publication year - 1999

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.63.955

Subject(s) - tbars , lactoferrin , lipid peroxidation , peptide , chemistry , biochemistry , thiobarbituric acid , antioxidant

Bovine lactoferrin (LF) and lactoferricin B (LFcin B), an antimicrobial peptide derived from bovine LF, inhibited thiobarbituric acid-reactive substance (TBARS) formation in a iron/ascorbate-induced liposomal phospholipid peroxidation system. The inhibition of TBARS formation occurred with N-acylated 9-mer peptides with a core sequence of LFcin B and, compared to LFcin B, their antioxidant effect was clearly observed at a concentration almost 100 times lower.

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