Asymmetric Reduction of Ethyl 2-methyl 3-oxobutanoate byChlorella | Zendy

Takayuki Kuramoto | Zendy; Kenzo IWAMOTO | Zendy; Minoru Izumi | Zendy; Mitsunori Kirihata | Zendy; Fumiki Yoshizako | Zendy

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Asymmetric Reduction of Ethyl 2-methyl 3-oxobutanoate byChlorella

Author(s) -

Takayuki Kuramoto,

Kenzo IWAMOTO,

Minoru Izumi,

Mitsunori Kirihata,

Fumiki Yoshizako

Publication year - 1999

Publication title -

bioscience biotechnology and biochemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.63.598

Subject(s) - chlorella pyrenoidosa , diastereomer , chlorella vulgaris , yield (engineering) , enantiomer , chemistry , methanol , stereochemistry , medicinal chemistry , organic chemistry , biology , chlorella , botany , algae , materials science , metallurgy

Chlorella pyrenoidosa Chick reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 53/47. The enantiomer excesses of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters were 89 and > 99ee% respectively. C. vulgaris and C. regularis afforded predominantly the syn-isomer, contrary to C. pyrenoidosa. The differences in the activity of reducing ethyl 2-methyl 3-oxobutanoate were observed among three strains of Chlorella. Addition of 2% metal salts slightly increased the chemical yield of the hydroxy ester.

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