Apoptosis-inducing Activity of Polyphenol Compounds Derived from Tea Catechins in Human Histiolytic Lymphoma U937 Cells | Zendy

Kouichi Saeki | Zendy; Mitsuaki Sano | Zendy; Toshio Miyase | Zendy; Yoshiyuki Nakamura | Zendy; Yukihiko Hara | Zendy; Yutaka Aoyagi | Zendy; Mamoru Isemura | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Apoptosis-inducing Activity of Polyphenol Compounds Derived from Tea Catechins in Human Histiolytic Lymphoma U937 Cells

Author(s) -

Kouichi Saeki,

Mitsuaki Sano,

Toshio Miyase,

Yoshiyuki Nakamura,

Yukihiko Hara,

Yutaka Aoyagi,

Mamoru Isemura

Publication year - 1999

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.63.585

Subject(s) - polyphenol , apoptosis , u937 cell , chemistry , catechin , food science , biochemistry , antioxidant

Polyphenolic compounds derived from tea catechins were examined for apoptosis-inducing activity in human histiolytic lymphoma U937 cells. (-)-Epigallocatechin gallate, theasinensin D, compound OH-5, theaflavin, and theaflavin digallate induced apoptosis as evidenced by DNA ladder formation, its inhibition by a caspase inhibitor, and chromatin condensation. Theasinensin D was the most potent inducer and the data suggest the importance of the number and three dimensional localization of their phenolic groups in this activity. These apoptosis-inducible compounds may be useful as a cancer chemopreventive and chemotherapeutic agent.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research