fcsA29Mutation is an Allele ofpolAGene ofEscherichia coli | Zendy

Kohji Nagano | Zendy; Masaaki Wachi | Zendy; Ayako Takada | Zendy; Fumie TAKAKU | Zendy; Takashi Hirasawa | Zendy; Kazuo Nagai | Zendy

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fcsA29Mutation is an Allele ofpolAGene ofEscherichia coli

Author(s) -

Kohji Nagano,

Masaaki Wachi,

Ayako Takada,

Fumie TAKAKU,

Takashi Hirasawa,

Kazuo Nagai

Publication year - 1999

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.63.427

Subject(s) - mutant , escherichia coli , biology , mutation , genetics , allele , exonuclease , gene , suppressor mutation , microbiology and biotechnology , polymerase

The cold-sensitive fcsA29 mutation of Escherichia coli was found to be a new type of cold-sensitive allele of the polA gene encoding DNA polymerase I, caused by an Asp(116)-->Asn change in the 5'-->3' exonuclease domain. The fcsA29 mutant showed typical polA mutant phenotypes such as UV sensitivity and unacceptability of recA mutation. Cold-sensitive growth of the mutant was suppressed by introduction of a sulA mutation, indicating that cell filamentation was due to the SOS response.

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