Differentiation in a Rat PC12 Cell Line Induced by Ostruthin and (-)-Bornyl Ferulate, Constituents of a Chinese Herbal Medicine | Zendy

Jianhua Qi | Zendy; Makoto Ojika | Zendy; Youji Sakagami | Zendy

Open Access

Differentiation in a Rat PC12 Cell Line Induced by Ostruthin and (-)-Bornyl Ferulate, Constituents of a Chinese Herbal Medicine

Author(s) -

Jianhua Qi,

Makoto Ojika,

Youji Sakagami

Publication year - 1999

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.63.1501

Subject(s) - neurite , traditional medicine , cytotoxicity , chemistry , traditional chinese medicine , isolation (microbiology) , cell culture , chinese herbs , biochemistry , biology , in vitro , medicine , bioinformatics , genetics , alternative medicine , pathology

A search for neuritogenic compounds in Chinese herbs resulted in the isolation of two known substances, ostruthin and (-)-bornyl ferulate, from Notopterygium incisum (and/or N. forbesii). Both compounds induced comparable neurite-like structures in 20% of rat PC12 cells at 2 micrograms/ml, and showed cytotoxicity at concentrations higher than 3 micrograms/ml.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research