Novel Bioactive Oxazolomycin Isomers Produced by Streptomyces albus JA3453. | Zendy

Hiroshi Kanzaki | Zendy; KenIchi Wada | Zendy; Teruhiko Nitoda | Zendy; Kazuyoshi Kawazu | Zendy

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Novel Bioactive Oxazolomycin Isomers Produced by Streptomyces albus JA3453.

Author(s) -

Hiroshi Kanzaki,

KenIchi Wada,

Teruhiko Nitoda,

Kazuyoshi Kawazu

Publication year - 1998

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.62.438

Subject(s) - agrobacterium tumefaciens , strain (injury) , stereochemistry , fermentation , streptomyces , streptomyces albus , antibacterial activity , chemistry , bacteria , botany , biology , food science , biochemistry , transformation (genetics) , gene , genetics , anatomy

Two novel oxazolomycin isomers, oxazolomycins B (2) and C (3), were isolated from the fermentation broth of an oxazolomycin-producing strain, Streptomyces albus JA3453. Both compounds are geometrical isomers of oxazolomycin (1), the configurations of their triene moieties being (4'E, 6'E, 8'E) (2) and (4'Z, 6'E, 8'E) (3) while that of oxazolomycin (1) is (4'Z, 6'Z, 8'E). Compounds 2 and 3 exhibited potent inhibitory activity against crown gall formation with the same MIC (0.8 microgram/disk) as oxazolomycin. Compounds 2 and 3 showed no antibacterial activity against Agrobacterium tumefaciens, in contrast to oxazolomycin which has specific anti-A. tumefaciens activity.

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