Multidrug Resistance Phenotype Conferred by Overexpressingbfr2+/pad1+/sks1+orpap1+Genes and Mediated bybfr1+Gene Product, a Structural and Functional Homologue of P-Glycoprotein inSchizosaccharomyces pombe | Zendy

Manabu Arioka | Zendy; Mutsuo KOUHASHI | Zendy; Koji Yoda | Zendy; Akira Takatsuki | Zendy; Makari Yamasaki | Zendy; Katsuhiko Kitamoto | Zendy

Open Access

Multidrug Resistance Phenotype Conferred by Overexpressingbfr2⁺/pad1⁺/sks1⁺orpap1⁺Genes and Mediated bybfr1⁺Gene Product, a Structural and Functional Homologue of P-Glycoprotein inSchizosaccharomyces pombe

Author(s) -

Manabu Arioka,

Mutsuo KOUHASHI,

Koji Yoda,

Akira Takatsuki,

Makari Yamasaki,

Katsuhiko Kitamoto

Publication year - 1998

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.62.390

Subject(s) - multiple drug resistance , gene , effector , mutant , biology , schizosaccharomyces pombe , atp binding cassette transporter , phenotype , transporter , genetics , microbiology and biotechnology , drug resistance

We investigated the mechanism of multidrug resistance conferred by overexpression of bfr2+/pad1+/sks1+ or pap1+ genes of Schizosaccharomyces pombe. Overexpression of bfr2+ did not confer multidrug resistance on a pap1-disrupted strain. In a mutant with bfr1+ (a putative membrane transporter which belongs to the ATP-binding cassette superfamily) disrupted, overexpression of either bfr2+ or pap1+ did not confer multidrug resistance. These findings suggest that bfr1+ acts as the most downstream effector of the multidrug resistance conferred by bfr2+ and pap1+ genes.

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