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Mapping of Human DNA-binding Nuclear Protein (NP220) to Chromosome Band 2p13.1-p13.2 and Its Relation to Matrin 3
Author(s) -
Katsuzumi Okumura,
Masahiro Nogami,
Yuichi Matsushima,
Kiyoshi Matsumura,
Kazuyasu Nakamura,
Hiroshi Taguchi,
Yasuo Kitagawa
Publication year - 1998
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.62.1640
Subject(s) - complementary dna , microbiology and biotechnology , dna , nuclear localization sequence , nuclear protein , biology , cdna library , fluorescence in situ hybridization , chromosome , genetics , gene , transcription factor
Human NP220 (hNP220) is a novel DNA-binding nuclear protein, which has an arginine/serine-rich motif and polypyrimidine tract-binding motif, and NP220s and matrin 3 are thought to form a novel family of nuclear proteins. We have determined a chromosomal localization of the cDNA encoding human NP220 to 2p13.1-p13.2 by using fluorescence in situ hybridization. Human matrin 3 cDNA was mapped to chromosomes 1p13.1-p21.1 and 5q31.3, demonstrating that these novel nuclear proteins with similar functions are on different chromosomes.

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